CleanMem is asking windows to do its cleanup on a process, cleanmem isn't doing the cleaning itself.
Yes, I know all that since I am using cleanmem for years and was always a big defender.

- But that doesn't change the fact that cleanmem gets this cleaning thing rolling.
Windows 7 memory management is far better than XP. After everything is started up in Windows 7, Windows cleans the memory up, that's why you see the drop.
Okay. - Sorry for thinking cleanmem was doing it (even if disabled).

If you are talking the file system cache that can be turned off in the cleanmem settings.
No, I am not talking about the file cache as I told cleanmem to leave that alone. - The thing is I want to speed up my system as much as possible (who wouldn't?) and of course it has then to use RAM as much as possible. - Always "cleaning" things is giving you slightly bigger chunks of unused RAM but that's nothing you want if system should be snappy.

Please don't misunderstand me. - I was for a very long time a great fan of cleanmem and installed it on every machine I came across (believer that I was *g*) and I even own 3 licenses of Pro version. - But testing systems and comparing them in terms of "felt speed" with and without regularly using cleanmem lead me recently to my conclusion that it is better to use Windows the built in RAM as much as possible. - I don't have any benefit if cleanmem keeps my RAM always only at 35-40 % usage. I want to use as much % RAM as possible for speed reasons. - Of course, if this would lead after a while to constant paging activity it would be a desaster. But the thing is with my usage pattern (I am not a gamer, not doing anything big like video cutting etc.) I am pretty fine with letting Win7 do it's thing. - As I said, it feels like now like a fish in water, my system.

And I really appreciate what cleanmem is doing for me. - Right now it is only telling me the RAM usage in different colours, but I plan to use the mentioned function to let cleanmem step in once a certain percentage of RAM use is reached.
CleanMem is running on a lot of machines. No one has had CleanMem cause any data integrity like you suggest.
Well, I did not tell you that to make you defend yourself.

- I am using cleanmem for many, many years and I also NEVER had an incident like that, nothing! - But my problem is/was with the new GUI (of pro version) and I think you should try to make that as reliable as possible. - Meaning that even stray conditions (you are obviously aware of) should be fixed or somehow avoided. I mean without user interaction (like changing manifest files). Maybe you will release a version that isn't freezing under certain conditions?

If the gui is crashing in the mini monitor then all you need to do is change the manifest file.
Well, thanks for this hint but I really think customers shouldn't have to to that on their own because most of them won't be able to do that and even more important: avoiding a (GUI) crash in the first place is better than doing it only after such consequences I had to go through.
I deleted that part of the manifest file (Mini_Monitor.exe) but I am not sure if I saw any change of the GUI though after restarting mini-monitor. So I can't tell if it works and I won't for sure provoke any other crash.

I have a very strong track record of how well cleanmem can help a system run. But every users system is different, so it may or may not be a benefit to you. Use it how ever you like, it is there if you need it. If not just get rid of it 
Yes, I know. - And I once was a firm believer too.

- And I really was sure that having cleanmem always running did very good things to my XP and later Win7 system. - But after feeling the difference of speed without having this cleanup every so and so minutes I had to change my mind about that.

- And of course, under different circumstances (for gamers maybe) cleanmem will make a huge difference and speeding things up, but on my everyday-use system it just kept my RAM "free" to often. - Doing it now ONLY when necessary is my solution and for that I am glad cleanmem exists!

For now I stay with manually cleaning but I really hope that GUI crashing thing is in a version to come "fixed" (in a way that doesn't make us customers edit manifest files) and THEN I happily will use cleanmems automatic cleaning function built in the new pro version I bought. ;-)
I have had to many debates over CleanMem and how it works and don't want to get into it again either. 
I probably read all of them in the last years and so I understand.

- But you should listen to your customers (that exist since pro version) and at least fix all you can about any crash you are aware of. ;-)
If you don't trust cleanmem that's fine.
No, I trust the "core engine" of cleanmem since I had it for years on many computers running without ANY (!) problem! - My distrust is only with the rather new and maybe not 100% stable GUI.

There are some nice system monitors out there that can give you the memory monitoring that you are looking for 
Well, I bought cleanmem and so I will using that if it's no problem.

And right now everything is fine: system is very smooth running, using the RAM I have bought for exactly this purpose (I did not buy it for cleaning it constantly *g*) and cleanmem shows me how much RAM is in use. - And if it turns RED I can do something about it and start "clean memory now".

So you see: happy customer! ;-)
best regards
Ma7